Research Associate
laurie-love-homan@uiowa.edu

Department of Pathology
1132 Medical Laboratories
500 Newton Road
University of Iowa
Iowa City, IA 52242-1109

Lab: 319-335-6514

Training

BA, Biology, University of Northern Iowa, Cedar Falls, Iowa (1980-1984)

Research

We are investigating the effect of a glycolytic inhibitor, 2-deoxy-glucose (2DG) in combination with an EGFr inhibitor erlotinib on head and neck cancer cell treatment. Also, I am currently developing a murine model for salivary cancer studies using the Justy mouse line.

Publications

Sobhakumari A, Schickling BM, Love-Homan L, Raeburn A, Fletcher EV, Case AJ, Domann FE, Miller FJ, Simons AL.Nox4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. Toxicol Appl Pharmacol. 2013 Jul31. doi:pii: S0041-008X(13)00322-0. 10.1016/j.taap.2013.07.013.[Epub ahead of print]

Yao C, Gaur Dixit U, Barker JH, Teesch LM, Love-Homan L, Donelson JE, Wilson ME. Attenuation of Leishmania infantum chagasi metacyclic promastigotes by sterol depletion. Infect Immun. 2013 Jul;81(7):2507-17. doi: 10.1128/IAI.00214-13. Epub 2013 Apr 29.

Sobhakumari A, Love-Homan L, Fletcher EV, Martin SM, Parsons AD, Spitz DR, Knudson CM, Simons AL. Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. PLos One. 2012;7(10);e48175. doi: 10.1371/journal.pone.0048175.Epub 2012 Oct 31.

Colin J. Thalhofer, Yani Chen, Bayan Sudan, Laurie Love-Homan, and Mary E. Wilson, Leukocytes Infiltrate the Skin and Draining Lymph Nodes in Response to the Protozoan Leishmania infantum chagasi Infection and Immunity, January 2011, p. 108-117, Vol. 79,No. 1

Colin J. Thalhofer, Joel W. Graff, Laurie Love-Homan, Suzanne M. Hickerson, Noah Craft, Stephen M. Beverley, and Mary E. Wilson In vivo Imaging of Transgenic Leishmania Parasites in a Live Host, JOVE: Journal of Video Imaging, Issue 41, July 2010

Horacio F. Olivo, Nury Perez-Hernandez, Dongmin Liu, Mary Iruthayanathan, Brianne O'Leary, Laurie L. Homan, and Joseph S. Dillon. Synthesis and Application of a Photoaffinity Analog of Dehydroepiandrosterone (DHEA). Bioorganic and Medicinal Chemistry Letters 2010, 20, 1153-5

Dongmin Liu, Brianne O’Leary, Mary Iruthayanathan, Laurie Love-Homan, Nury Perez-Hernandez, Horacio F. Olivio, Joseph S. Dillon. Evaluation of a novel photoactive and biotinylated dehydroepiandrosterone analog. Molecular and Cellular Endocrinology 328(2010)56-62

Dongmin Liu, Mary Iruthayanathan, Laurie L. Homan, Yiqiang Wang, Lingling Yang, Yao Wang and Joseph S. Dillon Dehydroepiandrosterone Stimulates Endothelial Proliferation and Angiogenesis through Extracellular Signal-Regulated Kinase 1/2-Mediated Mechanisms. Endocrinology Vol. 143 (3)889. (2008).

Dongmin Liu, Min Ren, Xinyu Bing, Corey Stotts, Sundeep Deorah, Laurie Love-Homan and Joseph S. Dillon Dehydroepiandrosterone inhibits intracellular calcium release in β-cells by a plasma membrane-dependent mechanism. Steroids Volume 71, Issue 8, August 2006, Pages 691-699

Dillon, JS. Lu, M., Bowen, S., Homan, LL. The recombinant rat glucagon-like peptide-1 receptor, expressed in an a-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release. Exp Clin Endocrinol Diabetes. 2005 Mar; 113 (3):182-9.

Liu, D., Homan, LL, Dillon, JS. Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic AMP dependent mechanism. Endocrinology. 2004 Dec; 145 (12):5532-9 Volume 145, No.12

Kovarik, J., P. Bosotti, L. Love-Homan, M. Pihlgren, H.L. Davis, P.H. Lambert, A.M. Krieg, and C.A. Siegrist. CpG oligodeoxynucleotides can circumvent the TH2 polarization of neonatal responses to vaccines but fail to fully redirect TH2 responses established by neonatal priming. Journal of Immunology. 162(3): 1611-7, 1999 Feb. 1.

Walker, P.S., T. Scharton-Kersten, A.M. Krieg, L. Love-Homan, E.D. Rowtown, M.C. Udey, and J.C. Vogel: Immunostimulatory oligonucleotides promote protective immunity and provide systemic therapy for Leishmaniasis via IL-12 and IFN-g dependent mechanisms. Proc. Natl. Acad. Sci. USA .96(12):6970-5, 1999 Jun 8.

Krieg, A.M., Wu, T. Weeratna, R., Efler, S.M., Love-Homan, L., Zhang, L., Yi, A.K., Short, D., and H. Davis. Sequence Motifs in Adenoviral DNA Which Block Immune Activation by Stimulatory CpG Motifs. Proc. Natl. Acad. Sci. USA. 96(21):12631-6, 1998 Oct 13.

Moldoveanu, Z., Love-Homan, L., Huang, W.Q., and Krieg, A.M... CpG DNA, a novel adjuvant for systemic and mucosal immunization with Influenza virus. Vaccine. 16(11-12):1216-24, 1998 Jul.

Arthur M. Krieg, Laurie Love-Homan, and John T. Harty. CpG DNA induces sustained Il-12 expression in vivo and resistance to L. monocytogenes challenge. 1997. Journal of Experimental Medicine, 161:2428-2434.

Garry A. Neil, Laurie Love-Homan, Deborah Clark, Fred Johlin Ulrich Zimmermann, Petra Gessner, Gerd Klock and Reiner Schnettler. Production of monoclonal antibodies specific to Hepatitis C. NASA Tech Briefs, August 1996. 20:8:97.

S. Kambhu and L. Love-Homan. Targeting a vector for high level expression in a subset of cancer cell lines. The American Society of Hematology, 36th Annual Meeting and Exposition, 1994. 188:1156.

Thomas F. Kresina, Adam Wisnewski, Laurie Love-Homan, Bernadette Ramirez and Garry A. Neil. Induction of hepatic pathology in SCID-hu mice engrafted with peripheral blood lymphocytes of patients with Schistosomiasis japonica. The Journal of Infectious Diseases. 170(3):733-6, 1994 Sept.

Zsuzsanna Fabry, Mari Waldschmidt, Dana Hendrickson, Judy Keiner, Laurie Love-Homan, Fumio Takei and Michael N. Hart. Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55. Journal of Neuroimmunology, 36(1992)1-11.

Michael N. Hart, Zsuzsanna Fabry, Laurie Love-Homan, Judy Keiner, Kathryn L. Sadewasser, and Steve Moore. Brain microvascular smooth muscle and endothelial cell produce granulocyte-macrophage colony stimulating factor and support colony formation of granulocyte-macrophage-like cells. American Journal of Pathology, vol. 141 (2), (1992)421-427.

Z. Fabry, J. Keiner, S. Ghoneim, L. Love-Homan, and M.N. Hart. Antigen transfer from brain microvascular smooth muscle to endothelium. Journal of Neuropathology and Experimental Neurology, 50(1991)348.

Mari Waldschmidt, Zsuzsanna Fabry, Judy Keiner, Laurie Love-Homan, and Michael N. Hart. Adhesion of splenocytes to brain microvascular endothelium in the Balb/c and SJL/j mouse systems. Journal of Neuroimmunology, 35(1991)191-200.